![]() ![]() Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Epigenetic memory underlies cell-autonomous heterogeneous behavior of hematopoietic stem cells. Hematopoietic stem cells are the major source of multilineage hematopoiesis in adult animals. Fundamental properties of unperturbed haematopoiesis from stem cells in vivo. Clonal dynamics of native haematopoiesis. Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells. Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy. SLAM family markers resolve functionally distinct subpopulations of hematopoietic stem cells and multipotent progenitors. ![]() Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche. Hematopoietic stem cell subtypes expand differentially during development and display distinct lymphopoietic programs. Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1. Long-term propagation of distinct hematopoietic differentiation programs in vivo. Those findings, coupled with single-cell expression analyses, suggest that a continuum of progenitors execute lymphoid and myeloid differentiation, rather than only uni-lineage progenitors’ being present downstream of stem cells.ĭykstra, B. Although most progenitors had the potential to develop into only one mature cell type (‘uni-lineage potential’), bi- and rarer multi-lineage progenitors were present among LMPPs, GMPs and MLPs. Here we demonstrated that lympho-myeloid progenitor populations in cord blood - lymphoid-primed multi-potential progenitors (LMPPs), granulocyte-macrophage progenitors (GMPs) and multi-lymphoid progenitors (MLPs) - were functionally and transcriptionally distinct and heterogeneous at the clonal level, with progenitors of many different functional potentials present. Multiple progenitor populations produce lymphoid and myeloid cells, but they remain incompletely characterized. The hierarchy of human hemopoietic progenitor cells that produce lymphoid and granulocytic–monocytic (myeloid) lineages is unclear. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |